Dry Granulation Machine Overview A dry granulation machine is a specialized pharmaceutical and chemical processing equipment designed to convert fine powders into dense, free-flowing granules without the use of liquid binders. This method is particularly suitable for moisture-sensitive or heat-sensitive materials, as it eliminates the need for drying, unlike wet granulation. The process primarily involves two key steps: compaction and size reduction. Working Principle The dry granulation process begins with the compaction of powder blends using a roller compactor. The powder is fed between two counter-rotating rollers, where high pressure is applied to form a compacted sheet or ribbon. This sheet is then milled or sieved to produce uniform granules of the desired particle size. The absence of liquid binders simplifies the process, reduces drying time, and minimizes the risk of degradation in sensitive formulations. Key Components 1. Feeding System – Ensures a consistent and controlled supply of powder to the compaction zone. 2. Roller Compactor – Applies high pressure to form dense compacts, with adjustable roll speed and pressure settings. 3. Milling Unit – Crushes the compacted material into granules, equipped with screens to control particle size distribution. 4. Control Panel – Allows operators to adjust parameters such as roller pressure, feed rate, and milling speed for optimal granule quality. Advantages - No Liquid Binders – Ideal for moisture-sensitive or heat-labile compounds. - Cost-Effective – Reduces energy consumption by eliminating drying steps. - Improved Flowability – Produces granules with better compressibility and flow properties for tablet pressing. - Dust Reduction – Minimizes airborne particles, enhancing workplace safety. Applications Dry granulation is widely used in pharmaceutical manufacturing for tablets, capsules, and powders. It is also applied in the food, chemical, and nutraceutical industries for processing hygroscopic or unstable materials. Considerations - Material properties (e.g., compressibility, cohesiveness) must be evaluated to optimize compaction pressure. - Proper maintenance of rollers and milling components ensures consistent granule quality. In summary, dry granulation machines offer an efficient, solvent-free solution for granulating powders, making them indispensable in industries requiring moisture control and process efficiency.